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Bristol Myers Squibb is accelerating neuroscience R&D using breakthroughs in human biology, biomarkers, and computational science to improve outcomes for patients with neurological conditions. The company is exploring new approaches to slow disease progression and alleviate symptoms.
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John", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1a9-384a-47bf-88d7-bdc33e4bf671", "text": "It's been very iterative, we have tested many hypotheses in the clinic and many of those have failed.", "simplified_text": "Neuroscience research is iterative many hypotheses have failed in clinic", "claim_maker": "S. John", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1aa-4426-4d62-908c-959bb9d02bcf", "text": "Until quite recently, the tools and the knowledge to help us make progress just didn't exist.", "simplified_text": "Tools knowledge to make neuroscience progress did not exist until recently", "claim_maker": "S. John", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1ab-43d3-4e77-bfc9-3de3a9d40412", "text": "We're at an incredible new frontier in neuroscience, where we have this deep understanding of the causal drivers of neurodegenerative and psychiatric diseases.", "simplified_text": "Neuroscience is at new frontier with deep understanding of causal drivers of neurodegenerative psychiatric diseases", "claim_maker": "K. 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Rhodes", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1ad-2001-4600-b3f8-7d5483640b9f", "text": "We have now blood-based biomarkers for diseases like Alzheimer's disease and Lou Gehrig's disease and these allow us to really monitor disease and even start to find patients who have pre-symptomatic disease.", "simplified_text": "Blood-based biomarkers exist for Alzheimer's disease Lou Gehrig's disease allowing disease monitoring pre-symptomatic patient identification", "claim_maker": "S. 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John", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1af-0aa9-4d23-b76d-dc71919de393", "text": "We see the deposition of toxic proteins of amyloid and tau and neuroinflammation within the brain and these occur in a time sequence.", "simplified_text": "Toxic proteins amyloid tau neuroinflammation deposit in brain in time sequence", "claim_maker": "R. Hargreaves", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1af-fc14-488f-8ca4-694dc0ffb788", "text": "We know where in the disease process we want to intervene.", "simplified_text": "Intervention point in disease process is known", "claim_maker": "R. Hargreaves", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1b0-f54e-4b57-8ca1-84ce03733403", "text": "We now have amyloid therapeutics which are able to slow the progression of the disease and future therapies now have the potential to add on to those and have an even bigger impact.", "simplified_text": "Amyloid therapeutics slow disease progression future therapies may have bigger impact", "claim_maker": "R. Hargreaves", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1b1-f514-4791-b06e-80239c3272e5", "text": "We have a holistic view of the disease, both from the pathology and from the symptomatology.", "simplified_text": "Holistic view of disease exists from pathology symptomatology", "claim_maker": "R. Hargreaves", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1b2-e5aa-4880-9488-477c3e12ff37", "text": "Whether we're developing an oral drug or an intravenous drug, an antibody or a small molecule, we want to use whatever modality we believe is best to interfere or interact with the underlying biology of disease, guided by that causal human biology.", "simplified_text": "Bristol Myers Squibb uses best modality to interact with disease biology guided by causal human biology", "claim_maker": "K. Rhodes", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1b3-dad8-45fb-882a-e9de13380022", "text": "Another key to advancing research and development in neuroscience is the use of informatics and predictive sciences at Bristol Myers Squibb.", "simplified_text": "Informatics predictive sciences are key to advancing neuroscience R&D at Bristol Myers Squibb", "claim_maker": "S. John", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1b4-d4a8-47b1-8620-604a957de188", "text": "The goal of these efforts is to enable our research and development teams to run the highest-quality investigational studies faster and more efficiently, and this will enable us to bring transformational medicines to patients more quickly.", "simplified_text": "Goal is to enable faster efficient high-quality investigational studies to bring transformational medicines to patients quickly", "claim_maker": "S. John", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1b5-d7e3-4ec6-8747-ab551cfc06a2", "text": "We have tremendous expertise that we're building across the Bristol Myers Squibb organization that will allow us to efficiently translate discoveries into the laboratory, into our clinical programs, ideally advancing molecules as quickly as possible to treat some devastating diseases.", "simplified_text": "Bristol Myers Squibb has expertise to efficiently translate discoveries into clinical programs advancing molecules to treat diseases", "claim_maker": "K. Rhodes", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1b6-d928-4145-b509-662a2ee0a8ee", "text": "One of the challenges that we still face is delivery of our medicines to the brain.", "simplified_text": "Challenge is medicine delivery to brain", "claim_maker": "K. Rhodes", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1b7-f79a-409a-adc9-11135b31e7e2", "text": "We're actively pursuing technologies that allow us to enhance the transport of molecules across the blood-brain barrier so that they can reach their site of action in the nervous system.", "simplified_text": "Bristol Myers Squibb actively pursues technologies to enhance molecule transport across blood-brain barrier", "claim_maker": "K. Rhodes", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1b9-0511-4c61-8ac4-5ad326713db4", "text": "I believe there's a tremendous progress on the horizon in neuroscience.", "simplified_text": "Tremendous progress is on horizon in neuroscience", "claim_maker": "K. Rhodes", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1b9-fea5-4f6a-95b3-03fedbf697b9", "text": "A strong foundation in causal human biology coupled with scientific creativity and serendipitous discovery have led to new and expanding approaches for the treatment of neurological conditions such as such as Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) and others with critical unmet needs.", "simplified_text": "Causal human biology scientific creativity serendipitous discovery led to new approaches for treating neurological conditions", "claim_maker": "The author", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1ba-f5f5-4adb-8fde-f93f9e1c5b35", "text": "Advancements in biomarkers, genetics and advanced computational methods have facilitated rapid progress within the field that was not previously possible.", "simplified_text": "Advancements in biomarkers genetics computational methods facilitated rapid progress", "claim_maker": "The author", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1bb-e549-4bcd-8642-a4ce1371ef88", "text": "Researchers at Bristol Myers Squibb are exploring a broad range of pathways, targets and modalities to slow or stop disease progression and\/or alleviate symptoms in neurological disorders with the aim of achieving the best possible outcomes for patients.", "simplified_text": "Bristol Myers Squibb researchers explore pathways targets modalities to slow stop disease progression alleviate symptoms", "claim_maker": "The author", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1bc-de18-4e91-8ddc-214ca0a94512", "text": "Neurodegenerative and neuropsychiatric conditions are inherently complex and represent some of the greatest challenges of our time.", "simplified_text": "Neurodegenerative neuropsychiatric conditions are complex great challenges", "claim_maker": "The author", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1bd-e0ce-4c08-890a-706241cbff2a", "text": "Our experts at Bristol Myers Squibb are boldly pursuing novel approaches with a clear vision to bring new, transformational therapies to patients living with these conditions.", "simplified_text": "Bristol Myers Squibb experts pursue novel approaches to bring transformational therapies to patients", "claim_maker": "The author", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1be-d564-4b67-b17d-bf3cbfcbe9a1", "text": "The neuroscience team at Bristol Myers Squibb is focused on neurological conditions for which there are currently limited options \u2014 such as Alzheimer\u2019s disease, autism spectrum disorder, bipolar disorder, multiple sclerosis and schizophrenia \u2014 and advancing research of new approaches that may modify the disease or alleviate symptoms.", "simplified_text": "Bristol Myers Squibb neuroscience team focuses on neurological conditions with limited options advancing research", "claim_maker": "The author", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1bf-bec7-495c-9043-9379e50ef423", "text": "Existing treatments still leave many patients and their families without the relief they urgently need.", "simplified_text": "Existing treatments leave many patients families without relief", "claim_maker": "Laura Gault", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1c0-bd98-4ad3-9f95-60c21151d76a", "text": "To address these unmet medical needs, our teams at Bristol Myers Squibb are exploring a broad range of mechanisms and targets with the goal of applying insights related to understanding brain pathways to develop therapies that will have a bigger impact for patients.", "simplified_text": "Bristol Myers Squibb explores mechanisms targets to develop therapies with bigger impact", "claim_maker": "Laura Gault", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1c1-cd1a-412f-9a9a-57bcc4a8af52", "text": "We have demonstrated efficacy for this approach in schizophrenia and are looking at how modulating these receptors can potentially treat cognitive and behavioral symptoms across a range of neuropsychiatric conditions.", "simplified_text": "Efficacy demonstrated in schizophrenia modulating receptors can treat cognitive behavioral symptoms", "claim_maker": "Laura Gault", "claim_subject_tags": [ "General" ], "confidence": 0.5, "context_type": "Website Article", "similarity_found": false, "linked_to": null, "similarity_score": null }, { "uuid": "9fc8a1c2-be90-4c15-9343-625e7c94552c", "text": "Human genetics has played an immeasurable role in the expansion of our scientific knowledge, revealing key causal human biology and new therapeutic targets.", "simplified_text": "Human genetics played immeasurable role in expanding scientific knowledge revealing causal biology therapeutic targets", "claim_maker": "Sally John", "claim_subject_tags": [ 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Science Firsthand: The renaissance of neuroscience R&D June 23, 2025 Bristol Myers Squibb is advancing neuroscience R&D through breakthroughs in human biology, biomarkers and computational scienceβpioneering new approaches to slow disease progression and improve outcomes for patients living with serious neurological conditions. [00:00-00:11] R. Hargreaves Scientists are inherently curious and they're persistent and breakthroughs don't really always happen easily, but they're resilient. [00:12-00:16] R. Hargreaves Understanding the brain is probably one of the most complex pieces of biology. [00:17-00:33] R. Hargreaves Not only is the access to it restricted, but also it's actually made up of millions and millions of cells that are interconnected, forming associated circuits that drive all of the emotions, motor behavior, senses. [00:34-00:40] R. Hargreaves And understanding these in health then allows us to examine them in disease. [00:45-00:50] K. Rhodes Neurodegenerat...
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