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When the edited cells were returned to patients, they could develop into red blood cells rife with hemoglobin. 1.000

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Simplified: When edited cells were returned to patients they could develop into red blood cells rife with hemoglobin

1 sources

1 week ago
They then used CRISPR to snip out the switch that would typically turn off the fetal hemoglobin gene. 1.000

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Simplified: They used CRISPR to snip out the switch that would turn off the fetal hemoglobin gene

1 sources

1 week ago
The researchers extracted immature blood cells from the bone marrow of the volunteers. 1.000

👤 The author 📋 News Article 🏷️ Science

Simplified: Researchers extracted immature blood cells from the bone marrow of volunteers

1 sources

1 week ago
These diseases impair hemoglobin, a protein in red blood cells that carries oxygen. 1.000

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Simplified: These diseases impair hemoglobin a protein in red blood cells that carries oxygen

1 sources

1 week ago
On June 12, researchers from CRISPR Therapeutics and Vertex, a Boston-based biotech firm, presented at a scientific meeting new results from their clinical trial involving 75 volunteers who had sickle... 1.000

👤 The author 📋 News Article 🏷️ Science , Statistical

Simplified: On June 12 researchers from CRISPR Therapeutics and Vertex presented new results from their clinical trial involving 75 volunteers with sickle-cell an...

1 sources

1 week ago
Caribou Biosciences, co-founded by Dr. Doudna, and CRISPR Therapeutics, co-founded by Dr. Charpentier, are both running clinical trials for CRISPR treatments that fight cancer in another way: by editi... 1.000

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Simplified: Caribou Biosciences and CRISPR Therapeutics are running clinical trials for CRISPR treatments that fight cancer by editing immune cells

1 sources

1 week ago
Researchers at KSQ Therapeutics, also in Cambridge, used CRISPR to discover a gene that is essential for the growth of certain tumors, for example, and last year, they began a clinical trial of a drug... 1.000

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Simplified: Researchers at KSQ Therapeutics used CRISPR to discover a gene essential for tumor growth and began a clinical trial of a drug that blocks the gene

1 sources

1 week ago
Cancer biologists began systematically altering every gene in cancer cells to see which ones mattered to the disease. 1.000

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Simplified: Cancer biologists began altering every gene in cancer cells to see which ones mattered to the disease

1 sources

1 week ago
Dr. Dow and his colleagues soon found that the method reliably snipped out pieces of DNA in human cancer cells. 1.000

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Simplified: Dr Dow and colleagues found the method reliably snipped out DNA pieces in human cancer cells

1 sources

1 week ago
Emmanuelle Charpentier, a French microbiologist with the Max Planck Unit for the Science of Pathogens in Berlin, who shared the Nobel Prize for Chemistry in 2020 with Dr. Doudna. 1.000

👤 The author 📋 News Article 🏷️ Science , Historical

Simplified: Emmanuelle Charpentier shared the Nobel Prize for Chemistry in 2020 with Dr Doudna

1 sources

1 week ago
Dr. Doudna did not win that race; the first two published papers came from two labs in Cambridge, Mass. — one at the Broad Institute of M.I.T. and Harvard, and the other at Harvard. 1.000

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Simplified: Dr Doudna did not win that race the first two papers came from two labs in Cambridge Mass

1 sources

1 week ago
In January 2013, five teams of scientists published studies in which they successfully used CRISPR in living animal or human cells. 1.000

👤 The author 📋 News Article 🏷️ Science , Historical

Simplified: In January 2013 five teams of scientists published studies using CRISPR in living animal or human cells

1 sources

1 week ago
For months Dr. Doudna oversaw a series of round-the-clock experiments to see if CRISPR might work not only in a test tube, but also in living cells. 1.000

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Simplified: For months Dr Doudna oversaw experiments to see if CRISPR might work in living cells

1 sources

1 week ago
They discovered that many of the DNA molecules had been cut at precisely the right spot. 1.000

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Simplified: They discovered many DNA molecules had been cut at the right spot

1 sources

1 week ago
Finally, they mixed the DNA, the RNA and molecular scissors together in test tubes. 1.000

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Simplified: They mixed DNA RNA and molecular scissors together in test tubes

1 sources

1 week ago
They then crafted another batch of RNA molecules, programming all of them to home in on the same spot on the DNA. 1.000

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Simplified: They crafted another batch of RNA molecules programming them to home in on the same spot on the DNA

1 sources

1 week ago
To test this revolutionary idea, they created a batch of identical pieces of DNA. 1.000

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Simplified: To test this idea they created a batch of identical pieces of DNA

1 sources

1 week ago
All they needed to do was make a matching piece of RNA. 1.000

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Simplified: They needed to make a matching piece of RNA

1 sources

1 week ago
As Dr. Doudna and Dr. Charpentier investigated CRISPR, they realized that the system might allow them to cut a sequence of DNA of their own choosing. 1.000

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Simplified: Dr Doudna and Dr Charpentier realized the CRISPR system might allow them to cut a DNA sequence of their own choosing

1 sources

1 week ago
These RNA molecules carry proteins with them that act like molecular scissors, slicing the viral genes and halting the infection. 1.000

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Simplified: RNA molecules carry proteins that act like molecular scissors slicing viral genes and halting infection

1 sources

1 week ago